Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles
Journal article published in 2021 by
Alexander V. Aksenov 
,
Nicolai A. Aksenov ,
Elena V. Aleksandrova,
Dmitrii A. Aksenov ,
Igor Y.-U. Grishin ,
Elena A. Sorokina,
Elena А. Sorokina,
Allison Wenger,
Michael Rubin
,
Nicolai A. Aksenov ,
Elena V. Aleksandrova,
Dmitrii A. Aksenov ,
Igor Y.-U. Grishin ,
Elena A. Sorokina,
Elena А. Sorokina,
Allison Wenger,
Michael Rubin
This paper is made freely available by the publisher.
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Abstract
The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.