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Wiley, Angewandte Chemie International Edition, 33(52), p. 8557-8560, 2013

DOI: 10.1002/anie.201302149

Wiley, Angewandte Chemie, 33(125), p. 8719-8722

DOI: 10.1002/ange.201302149

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Visualization and isolation of langerhans islets by a fluorescent probe PiY

Journal article published in 2013 by Nam-Young Kang, Sung-Chan Lee, Sung-Jin Park, Hyung-Ho Ha, Seong-Wook Yun, Elena Kostromina, Natalia Gustavsson, Yusuf Ali ORCID, Yogeswari Chandran, Hang-Suk Chun, MyungAe Bae, Jin Hee Ahn, Weiping Han, George K. Radda, Young-Tae Chang
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Lighting up the pancreas: A pancreatic beta cell selective probe PiY (green, see picture) was developed, which stains Langerhans islets in live animals without toxicity or side effects. Through tail-vein injection, PiY allowed for a comparison of the islets between healthy and diabetic mice. PiY also facilitated the isolation of healthy Langerhans islets using a fluorescence-guided surgical procedure.