Published in
American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 6(321), p. H1096-H1102, 2021
DOI: 10.1152/ajpheart.00542.2021
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Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension
Journal article published in 2021 by
William E. Hughes 
,
Joe Hockenberry,
Bradley Miller ,
Andrey Sorokin ,
Andreas M. Beyer
,
Joe Hockenberry,
Bradley Miller ,
Andrey Sorokin ,
Andreas M. Beyer
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Abstract
We demonstrate that the modulation of p66Shc signaling impairs cerebral artery myogenic tone in a low renin model of hypertension. This impairment is dependent upon the genetic background, as modulated p66Shc signaling in Sprague-Dawley rats does not impair cerebral artery myogenic tone.