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American Association for the Advancement of Science, Science Advances, 44(7), 2021

DOI: 10.1126/sciadv.abh1448

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In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

Journal article published in 2021 by Georg Meisl ORCID, Eric Hidari, Kieren Allinson ORCID, Timothy Rittman ORCID, Sarah L. DeVos ORCID, Justin S. Sanchez ORCID, Catherine K. Xu ORCID, Karen E. Duff ORCID, Keith A. Johnson ORCID, James B. Rowe ORCID, Bradley T. Hyman ORCID, Tuomas P. J. Knowles ORCID, David Klenerman ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Local replication doubles the number of tau aggregate in Alzheimer’s disease only once every 5 years, limiting the overall rate.