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IOS Press, Journal of Alzheimer's Disease, 1(34), p. 139-144

DOI: 10.3233/jad-121861



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You Don’t Say: Dynamic Aphasia, Another Variant of Primary Progressive Aphasia?

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This paper is available in a repository.

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Data provided by SHERPA/RoMEO


Primary progressive aphasia (PPA) is a language predominant neurodegenerative disorder that has three recognized variants: nonfluent/agrammatic, semantic, and logopenic. This report describes a 60-year-old man who presented with a progressive decline in verbal output that does not fit the currently accepted PPA subtypes. The patient exhibited a paucity of verbal output and impaired phonemic fluency with minimal associated language, cognitive, or behavioral deficits. Focal cortical thinning/hypometabolism of the left superior frontal region and a cerebrospinal fluid profile not consistent with Alzheimer’s disease pathology were identified. This case of isolated progressive dynamic aphasia extends the current boundaries of PPA diagnostic variants.