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American Association for the Advancement of Science, Science Advances, 45(7), 2021

DOI: 10.1126/sciadv.abg8583

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High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

Journal article published in 2021 by Marcella van Hoolwerff ORCID, Alejandro Rodríguez Ruiz ORCID, Marga Bouma ORCID, H. Eka D. Suchiman ORCID, Roman I. Koning ORCID, Carolina R. Jost ORCID, Aat A. Mulder ORCID, Christian Freund, Farshid Guilak ORCID, Yolande F. M. Ramos ORCID, Ingrid Meulenbelt ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Fibronectin binding to collagen type II is crucial for articular chondrocytes to stay in a healthy steady state.