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American Physiological Society, AJP - Endocrinology and Metabolism, 6(321), p. E753-E765, 2021

DOI: 10.1152/ajpendo.00219.2021

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Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart

Journal article published in 2021 by Rui Shang, Nathaniel Lal, Chae Syng Lee, Yajie Zhai, Karanjit Puri, Oscar Seira, Robert C. Boushel, Ibrahim Sultan ORCID, Markus Räsänen, Kari Alitalo, Bahira Hussein, Brian Rodrigues ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

In hearts overexpressing vascular endothelial growth factor B (VEGFB), besides its known angiogenic response, multiple regulatory mechanisms lowered coronary LPL. This was accompanied by limited cardiac lipid metabolite accumulation with an augmentation of cardiac insulin action. Our data for the first time links VEGFB to coronary LPL in regulation of cardiac metabolism. VEGFB may be cardioprotective in metabolic disorders like diabetes.