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Royal Society of Chemistry, Chemical Science, 46(12), p. 15374-15381, 2021

DOI: 10.1039/d1sc04809k

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Luminol anchors improve the electrochemical-tyrosine-click labelling of proteins

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We assessed the relative efficiencies of tyrosine anchors in the electrochemical conjugation of peptides and proteins. Luminol derivatives showed faster reaction kinetics, complete tyrosine-chemoselectivity, and possible double modification.