Published in
American Physiological Society, American Journal of Physiology - Gastrointestinal and Liver Physiology, 1(322), p. G66-G78, 2022
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Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders
,
Ayame Saito,
Vi Pham,
Agata Szymaszkiewicz,
Arisbel B. Gondin,
Sadia Alvi,
Kiliana Marique,
Priyank Shenoy,
Nicholas A. Veldhuis,
Jakub Fichna,
Meritxell Canals,
Arthur Christopoulos,
Celine Valant ,
Daniel P. Poole
Full text: Unavailable
Abstract
This study assesses the use of positive allosteric modulation as a pharmacological approach to enhance opioid receptor signaling in the enteric nervous system. We demonstrate that selective modulation of endogenous delta opioid receptor signaling can suppress colonic motility without causing constipation. We propose that allosteric modulation of opioid receptor signaling may be a therapeutic strategy to normalize gastrointestinal motility in conditions such as irritable bowel syndrome.