Discovery of an Antarctic Ascidian-Associated Uncultivated Verrucomicrobia with Antimelanoma Palmerolide Biosynthetic Potential
Journal article published in 2021 by
Alison E. Murray 
,
Chien-Chi Lo ,
Hajnalka E. Daligault ,
Nicole E. Avalon ,
Robert W. Read ,
Karen W. Davenport ,
Mary L. Higham ,
Yuliya Kunde ,
Armand E. K. Dichosa ,
Bill J. Baker ,
Patrick S. G. Chain
,
Chien-Chi Lo ,
Hajnalka E. Daligault ,
Nicole E. Avalon ,
Robert W. Read ,
Karen W. Davenport ,
Mary L. Higham ,
Yuliya Kunde ,
Armand E. K. Dichosa ,
Bill J. Baker ,
Patrick S. G. Chain
This paper is made freely available by the publisher.
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Abstract
Palmerolide A has potential as a chemotherapeutic agent to target melanoma. We interrogated the microbiome of the Antarctic ascidian, Synoicum adareanum , using a cultivation-independent high-throughput sequencing and bioinformatic strategy.