Abstract The Chinese CubeSat Mission, Gamma Ray Integrated Detectors (GRID), recently detected its first gamma-ray burst, GRB 210121A, which was jointly observed by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM). This burst is confirmed by several other missions, including Fermi and Insight-HXMT. We combined multimission observational data and performed a comprehensive analysis of the burst’s temporal and spectral properties. Our results show that the burst is relatively special in its high peak energy, thermal-like low-energy indices, and large fluence. By putting it to the E _p –E _γ,iso relation diagram with assumed distance, we found that this burst can be constrained at the redshift range of [0.3, 3.0]. The thermal spectral component is also confirmed by the direct fit of the physical models to the observed spectra. Interestingly, the physical photosphere model also constrained a redshift of z ∼ 0.3 for this burst, which helps us to identify a host galaxy candidate at such a distance within the location error box. Assuming that the host galaxy is real, we found that the burst can be best explained by the photosphere emission of a typical fireball with an initial radius of r ₀ ∼ 3.2 × 10⁷ cm.