Published in
Royal Society of Chemistry, Chemical Science, 1(13), p. 210-217, 2022
DOI: 10.1039/d1sc04420f
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Discovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity
Journal article published in 2022 by
Ana S. Pina 
,
Leonor Morgado ,
Krystyna L. Duncan,
Sara Carvalho ,
Henrique F. Carvalho ,
Arménio J. M. Barbosa ,
Beatriz de P. Mariz,
Inês P. Moreira,
Daniela Kalafatovic,
Bruno M. Morais Faustino ,
Vishal Narang,
Tong Wang,
Charalampos G. Pappas ,
Isabel Ferreira ,
A. Cecília A. Roque
and other authors.
,
Leonor Morgado ,
Krystyna L. Duncan,
Sara Carvalho ,
Henrique F. Carvalho ,
Arménio J. M. Barbosa ,
Beatriz de P. Mariz,
Inês P. Moreira,
Daniela Kalafatovic,
Bruno M. Morais Faustino ,
Vishal Narang,
Tong Wang,
Charalampos G. Pappas ,
Isabel Ferreira ,
A. Cecília A. Roque
and other authors.
This paper is made freely available by the publisher.
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Abstract
Phage-display screening on self-assembled tyrosine-phosphate ligands enables the identification of oligopeptides selective to dynamic supramolecular targets, with the lead peptide showing a preferred hairpin-like conformation and catalytic activity.