Titanium Grade 4 (Ti G4) is widely used in medicine for dental implants. The failure-free life of implants depends on their properties such as resistance to wear and friction processes. This paper presents an analysis of the influence of sandblasting on tribological wear of commercial dental implants made of TiG4 in artificial saliva. Tribological wear measurements were performed in a reciprocating motion in the ball-on-disc system. The scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS) method was used to characterize the surface of the implants before and after the tribological wear test. The microhardness of Ti G4 was measured before and after sandblasting by the Vickers method. The contact angle was determined by the method of sitting drop in air. The residual stress test using the X-Ray Diffraction (XRD) single-{hkl} sin2ψ method was carried out. The compressive residual stress of 324(7) MPa and surface hardening of Ti G4 was revealed after sandblasting with Al2O3 particles of 53–75 μm in diameter. It was found that sandblasting changes the surface wettability of Ti G4. The intermediate wettability of the mechanically polished surface and the hydrophobicity of the sandblasted surface was revealed. Sandblasting reduces the tribological wear and friction coefficient of Ti G4 surface in saliva. The three-body abrasion wear mechanism was proposed to explain the tribological wear of Ti G4 in saliva.