A new species of Lepanthes from southwestern Colombia is presented here. Lepanthes farallonensis belongs to the informal group “manabina”, which comprises species with concave and commonly pubescent leaves, flowers resting at the adaxial side of the leaves, and the synsepal with short to long tails. Lepanthes farallonensis is similar to L. smaragdina in the broadly ovate dorsal sepal but differs in the conspicuously twisted upper lobes of the petals, outwardly bent and a depression at the center of the laminae of the lip.