Published in

Rockefeller University Press, Journal of Experimental Medicine, 2(219), 2021

DOI: 10.1084/jem.20212326

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mTEC damage risks immune recovery

Journal article published in 2021 by Yousuke Takahama ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Whether autologous hematopoietic stem cell transplantation is free from graft-versus-host disease is controversial. Alawam et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211239) now demonstrate that prolonged damage in thymic medullary epithelial cells causes the failure in self-tolerance in newly generated T cells and provokes post-transplant autoimmunity.