Herein, we show the prediction of the viscosity of a binary mixture of bitumen and light oil using a feedforward neural network with backpropagation model, as compared to empirical models such as the reworked van der Wijk model (RVDM), modified van der Wijk model (MVDM), and Al-Besharah. The accuracy of the ANN was based on all of the samples, while that of the empirical models was analyzed based on experimental results obtained from rheological studies of three binary mixtures of light oil (API 32°) and bitumen (API 7.39°). The classical Mehrotra–Svrcek model to predict the viscosity of bitumen under temperature and pressure, which estimated bitumen results with an %AAD of 3.86, was used along with either the RVDM or the MVDM to estimate the viscosity of the bitumen and light oil under reservoir temperature and pressure conditions. When both the experimental and literature data were used for comparison to an artificial neural network (ANN) model, the MVDM, RVDM and Al-Besharah had higher R2 values.