Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2(66), 2022
DOI: 10.1128/aac.01845-21
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Staphylococcus aureus Efflux Pumps and Tolerance to Ciprofloxacin and Chlorhexidine following Induction by Mupirocin
Journal article published in 2022 by
Q. C. Truong-Bolduc,
Y. Wang,
J. L. Reedy,
J. M. Vyas 
,
D. C. Hooper
,
D. C. Hooper
This paper is made freely available by the publisher.
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Abstract
Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact norA and mepA , respectively.