Published in
American Society for Microbiology, Microbiology Spectrum, 3(9), 2021
DOI: 10.1128/spectrum.01497-21
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Cutibacterium acnes Induces the Expression of Immunosuppressive Genes in Macrophages and is Associated with an Increase of Regulatory T-Cells in Prostate Cancer
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Jessica Carlsson ,
Larry Greenberg,
Jonny Wijkander,
Bo Söderquist ,
Ann Erlandsson
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Abstract
In an immune suppressive tumor microenvironment constituted by immunosuppressive cells and immunosuppressive mediators, tumors may improve their ability to give rise to a clinically relevant cancer. In the present study, we found that C. acnes might contribute to an immunosuppressive environment by recruiting regulatory T cells and by increasing the expression of immunosuppressive mediators such as PD-L1, CCL17, and CCL 18.