Published in
American Physiological Society, AJP - Endocrinology and Metabolism, 2(322), p. E141-E153, 2022
DOI: 10.1152/ajpendo.00365.2021
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Extracellular flux analyses reveal differences in mitochondrial PBMC metabolism between high-fit and low-fit females
Journal article published in 2022 by
Joëlle J. E. Janssen 
,
Bart Lagerwaard ,
Mojtaba Porbahaie ,
Arie G. Nieuwenhuizen,
Huub F. J. Savelkoul,
R. J. Joost van Neerven ,
Jaap Keijer ,
Vincent C. J. de Boer
,
Bart Lagerwaard ,
Mojtaba Porbahaie ,
Arie G. Nieuwenhuizen,
Huub F. J. Savelkoul,
R. J. Joost van Neerven ,
Jaap Keijer ,
Vincent C. J. de Boer
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Abstract
Mitochondrial metabolism was significantly higher in PBMCs from high-fit than from low-fit females. This was unrelated to PBMC composition and not impacted by a recent bout of exercise. Our study reveals a link between PBMC metabolism and levels of aerobic fitness, increasing the relevance of PBMC metabolism as a marker to study the impact of lifestyle factors on human health.