Abstract In contrast enhancement ultrasound (CEUS), the vasculature image can be formed from nonlinear echoes arising from microbubbles in a blood flow. The use of binary-coded pulse compression is promising for improving the contrast of CEUS images by suppressing background noise. However, the amplitudes of nonlinear echoes can be reduced, and sidelobes by nonlinear echoes can occur depending on the binary code. Optimal Golay codes with slight nonlinear-echo reduction and nonlinear sidelobe have been proposed. In this study, CEUS images obtained by optimal Golay pulse compression are evaluated through experiments using Sonazoid microbubbles flowing in a tissue-mimicking phantom.