Abstract The direct measurement of the universe’s expansion history and the search for terrestrial planets in habitable zones around solar-type stars require extremely high-precision radial-velocity measures over a decade. This study proposes an approach for enabling high-precision radial-velocity measurements from space. The concept presents a combination of a high-dispersion densified pupil spectrograph and a novel line-of-sight monitor for telescopes. The precision of the radial-velocity measurements is determined by combining the spectrophotometric accuracy and the quality of the absorption lines in the recorded spectrum. Therefore, a highly dispersive densified pupil spectrograph proposed to perform stable spectroscopy can be utilized for high-precision radial-velocity measures. A concept involving the telescope’s line-of-sight monitor is developed to minimize the change of the telescope’s line of sight over a decade. This monitor allows the precise measurement of long-term telescope drift without any significant impact on the Airy disk when the densified pupil spectra are recorded. We analytically derive the uncertainty of the radial-velocity measurements, which is caused by the residual offset of the lines of sight at two epochs. We find that the error could be reduced down to approximately 1 cm s⁻¹, and the precision will be limited by another factor (e.g., wavelength calibration uncertainty). A combination of the high-precision spectrophotometry and the high spectral resolving power could open a new path toward the characterization of nearby non-transiting habitable planet candidates orbiting late-type stars. We present two simple and compact highly dispersed densified pupil spectrograph designs for cosmology and exoplanet sciences.