Dissemin is shutting down on January 1st, 2025

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Public Library of Science, PLoS ONE, 1(7), p. e29838, 2012

DOI: 10.1371/journal.pone.0029838

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“One-Size-Fits-All”? Optimizing Treatment Duration for Bacterial Infections

Journal article published in 2012 by Patricia Geli, Ramanan Laxminarayan, Michael Dunne, David L. Smith ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Historically, antibiotic treatment guidelines have aimed to maximize treatment efficacy and minimize toxicity, but have not considered the evolution of antibiotic resistance. Optimizing the duration and dosing of treatment to minimize the duration of symptomatic infection and selection pressure for resistance simultaneously has the potential to extend the useful therapeutic life of these valuable life-saving drugs without compromising the interests of individual patients.