Abstract This study aimed to test the predictive capacity of pathological traits of personality and career adaptability on four constructs that compose the well-being at work: work engagement, job satisfaction, burnout, and workaholism. A total of 204 Brazilian working adults (M age = 34.02, SD = 10.39) participated in the study, which responded to scales measuring pathological traits, career adaptability resources, and well-being components at work. Our findings indicate that pathological traits are, in general, negatively related to job satisfaction and work engagement and positively associated with burnout and workaholism. After the insertion of career adaptability, there was an increase in most of the models' explanation. The contribution of adaptability was significant only for job satisfaction prediction.