According to World Health Organization (WHO), the leading cause of fatalities and injuries is rear-ending collision in vehicles. The critical challenge of the technologically rich transportation system is to reduce the chances of accidents between vehicles. For this purpose, it is especially important to analyze the factors that are the cause of accidents. Based on these factors’ results, this paper presents a driver assistance system for collision avoidance. There are many factors involved in collisions in the existing literature from which we identified some factors which can affect the accident occurrence probability. However, with advancements in the technologies of autonomous vehicles, these factors can be controlled using an onboard driver assistance system. We used MATLAB’s Fuzzy Inference System Tool to analyze the categories of accident contributing factors. Fuzzy results are validated using the VOMAS agent in the NetLogo simulation model. The proposed system can inform the vehicle’s automated system when chances of an accident are higher so that the vehicle may take control from the driver. The proposed research is extremely helpful in handling various kinds of factors involved in accidents. The results of the experiments demonstrated that multi-factor-enabled vehicles could better avoid collision as compared to other vehicles.