Regnase-1 Deficiency Restrains Klebsiella pneumoniae Infection by Regulation of a Type I Interferon Response
Journal article published in 2022 by
Giraldina Trevejo-Nuñez,
Becky Lin,
Li Fan,
Felix E. Y. Aggor 
,
Partha S. Biswas,
Kong Chen,
Sarah L. Gaffen
,
Partha S. Biswas,
Kong Chen,
Sarah L. Gaffen
This paper is made freely available by the publisher.
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Abstract
Klebsiella pneumoniae (KP) can cause life-threatening bacterial pneumonia and is the third most common cause of ventilator-associated pneumonia in the United States. Host inflammatory responses to infection are necessary to control disease, yet at the same time can cause collateral damage or immunopathology.