Oxford University Press, Open Forum Infectious Diseases, 3(9), 2022
DOI: 10.1093/ofid/ofac031
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Abstract We describe the first documented case of Jamestown Canyon virus (JCV) in North Carolina, which occurred in a liver transplant patient who presented acutely with headache, aphasia, and confusion. This is also the first report of recovery from JCV encephalitis following treatment with intravenous immune globulin.