AbstractSplicing systems are a form of DNA computing as they mimic the recombination process among DNA molecules. This work discusses the use of splicing systems to build automatic tools for reproducing human beings’ creativity, in the context of automatic music composition. More specifically, this work describes three general splicing system approaches for automatic music composition, and their application to two specific cases, namely composing 4-voice music and composing Jazz solos in a given style. Examples of music composed by the systems are presented.