Dissemin is shutting down on January 1st, 2025

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Oxford University Press, Clinical Infectious Diseases, 6(75), p. 1073-1077, 2022

DOI: 10.1093/cid/ciac140

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The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland

Journal article published in 2022 by Adam Trickey ORCID, Sara Croxford, Eva Emanuel ORCID, Samreen Ijaz, Matthew Hickman, Joanna Kesten, Clare Thomas, Claire Edmundson, Monica Desai, Peter Vickerman
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioral surveys among PWID for 2016/18/19 (n = 1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted odds ratio = 0.24, 95% confidence interval [CI]: .08–.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.