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Wiley, American Journal of Medical Genetics, 3(96), p. 360-364, 2000

DOI: 10.1002/1096-8628(20000612)96:3<360::aid-ajmg24>3.0.co;2-e

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5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait.

Journal article published in 2000 by Sylvie Blairy, Isabelle Massat, Luc Staner, Olivier Le Bon, Sofie Van Gestel, Christine Van Broeckhoven, O. Lebon, Peter Raeymaekers, Van Christine Broeckhoven, Christiane Hilger ORCID, François Hentges, Daniel Souery, Julien Mendlewicz
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The purpose [corrected] of this study was to investigate the relationship between bipolar disorder and the harm avoidance personality trait (HA), and the genetic contribution of the polymorphic DNA variation T102C in exon 1 of 5-HTR2a (chromosome 13q14-21) in bipolar disorder and HA personality trait. Forty bipolar patients and 89 normal subjects completed the TPQ questionnaire and were genotyped for 5-HT2a. Bipolar patients scored higher than normal subjects on the HA dimension. However, no contribution of the 5-HTR2a polymorphism on the bipolar disorder or on the HA personality trait emerged. Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect. ; Journal Article ; Research Support, Non-U.S. Gov't ; SCOPUS: ar.j ; info:eu-repo/semantics/published