With this study, we report on the reliability of the most recent commercial UVC LED devices. The current COVID-19 pandemic urged the development of antiviral technologies, and one of the most effective is based on UVC irradiation, which can be effectively achieved by means of Deep UV LEDs. The development of antiviral systems based on UVC LEDs strongly depends on their efficacy and reliability. We propose an in-depth analysis of four different state-of-the-art commercial LEDs suitable for disinfection applications. LEDs have been subjected to a controlled stress test near their application limits, and their reliability and characteristics have been analyzed and studied. Results indicate a still limited reliability, with a degradation possibly related to an increase in Shockley–Read–Hall (SRH) recombination. Finally, some relevant product design suggestions will be proposed based on the results of this work.