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Thieme Gruppe, Experimental and Clinical Endocrinology and Diabetes, 06(121), p. 361-367, 2013

DOI: 10.1055/s-0033-1345122

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IGF2 Gene Polymorphisms and IGF-II Concentration are Determinants of Longitudinal Weight Trends in Type 2 Diabetes.

Journal article published in 2013 by R. P. Narayanan, B. Fu, A. Payton, J. E. Hudson, R. L. Oliver, Fu B Payton A Hudson JE Oliver RL Anderson SG Siddals KW White A Ollier WER Heald AH & Gibson Jm Narayanan Rp, K. W. Siddals, S. G. Anderson ORCID, A. White, W. E. R. Ollier, A. H. Heald, J. M. Gibson, Fu B Payton A Hudson JE Oliver RL Anderson SG Siddals KW White A Ollier WE Heald AH Gibson J.-M. Narayanan Rp
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The hypothesis of the study was that IGF2 gene polymorphisms were associated with longitudinal trends in weight through modification of IGF-II concentration.Observational study that explored associations of the IGF2 gene and baseline circulating IGF-II concentration with ‘real-world' longitudinal trends in body-mass index in a type 2 diabetes population.26 haplotype tagging single nucleotide polymorphisms (SNPs) from the IGF2 and H19 genes were studied in 485 Caucasian individuals in the Salford Longitudinal Diabetes Cohort. A generalised-estimating equation (GEE) model was used to separately study the association of SNPs and IGF-II concentration with 8-year longitudinal trends in body-mass index.High serum IGF-II concentration at baseline was associated with weight loss over the study period (β=-0.006, 95% CI -0.009 to -0.002, p