Broad Neutralization of SARS-CoV-2 Variants, Including Omicron, following Breakthrough Infection with Delta in COVID-19-Vaccinated Individuals
Journal article published in 2022 by
Thomas Lechmere,
Luke B. Snell 
,
Carl Graham,
Jeffrey Seow,
Zayed A. Shalim,
Themoula Charalampous,
Adela Alcolea-Medina,
Rahul Batra,
Gaia Nebbia,
Jonathan D. Edgeworth,
Michael H. Malim,
Katie J. Doores
,
Carl Graham,
Jeffrey Seow,
Zayed A. Shalim,
Themoula Charalampous,
Adela Alcolea-Medina,
Rahul Batra,
Gaia Nebbia,
Jonathan D. Edgeworth,
Michael H. Malim,
Katie J. Doores
This paper is made freely available by the publisher.
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Abstract
COVID-19 vaccines have been vital in controlling SARS-CoV-2 infections and reducing hospitalizations. However, breakthrough SARS-CoV-2 infections (BTI) occur in some vaccinated individuals. Here, we study how BTI impacts on the potency and the breadth of the neutralizing antibody response. We show that a Delta infection in COVID-19-vaccinated individuals provides potent neutralization against the current SARS-CoV-2 variants of concern, including the Omicron variant.