Published in
American Society for Microbiology, Journal of Virology, 7(96), 2022
DOI: 10.1128/jvi.00057-22
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Heparanase Blockade as a Novel Dual-Targeting Therapy for COVID-19
Journal article published in 2022 by
Jingyu Xiang,
Mijia Lu,
Min Shi,
Xiaogang Cheng,
Kristin A. Kwakwa,
Jennifer L. Davis,
Xinming Su 
,
Suzanne J. Bakewell,
Yuexiu Zhang,
Francesca Fontana ,
Yalin Xu,
Deborah J. Veis,
John F. DiPersio,
Lee Ratner,
Ralph D. Sanderson
and other authors.
,
Suzanne J. Bakewell,
Yuexiu Zhang,
Francesca Fontana ,
Yalin Xu,
Deborah J. Veis,
John F. DiPersio,
Lee Ratner,
Ralph D. Sanderson
and other authors.
This paper is made freely available by the publisher.
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Abstract
The complex pathogenesis of COVID-19 consists of two major pathological phases: an initial infection phase elicited by SARS-CoV-2 entry and replication and an inflammation phase that could lead to tissue damage, which can evolve into acute respiratory failure or even death. While the development and deployment of vaccines are ongoing, effective therapy for COVID-19 is still urgently needed.