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Springer, BIOspektrum, 2(28), p. 132-134, 2022

DOI: 10.1007/s12268-022-1742-5

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Mitochondrien als universelle Sensoren der akuten Hypoxie?

Journal article published in 2022 by Anika Nolte, Oleg Pak, Natascha Sommer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractAdaptation to acute hypoxia through cardiorespiratory responses is mediated by specialized cells in the carotid body and pulmonary vasculature to optimize systemic arterial oxygenation. Acute oxygen sensing thus is a fundamental pre-requisite for aerobic life. Recent studies unravelled basic oxygen sensing mechanisms involving the mitochondrial cytochrome c oxidase subunit 4 isoform 2 that regulates the release of mitochondrial reactive oxygen species and subsequent acute hypoxic responses.