Dissemin is shutting down on January 1st, 2025

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MDPI, International Journal of Molecular Sciences, 7(23), p. 3860, 2022

DOI: 10.3390/ijms23073860

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Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB management as a result of its connection with oxidative balance. Our review encourages the possible in vivo benefit of a joint administration with other vitamins, such as vitamin A, which share a known antimycobacterial action with vitamin D. However, considering the low incidence of side effects even at high dosages and its low cost, it would be advisable to assess vitamin D level both in patients with active TB and high-risk groups and administer it, at least to reach sufficiency levels.