AbstractCollaborative programs that facilitate innovation to deliver value at scale require attention to effective program design, management, governance, and leadership. The CGIAR has experimented with different collaborative program design options over its 50-year history, most recently with the CGIAR Research Programs (CRPs) implemented from 2012 to 2021. This chapter examines the structure and processes of the CGIAR Research Program on Roots, Tubers and Bananas (RTB). It unpacks the constituent institutional innovations that underpinned the RTB program, their key design principles, how they evolved over the 10 years of the program, the innovations achieved, and the outcomes to which they contributed. Turbulence and transformations in the CGIAR system influenced the CRPs’ emergence, design, and delivery. In this chapter, we discuss the RTB approach to collaborative governance and management as complex institutional innovations operating within this broader, dynamic system. This includes attention to opportunities, limitations, and other contextual factors influencing RTB’s work. Institutional innovations include stakeholder consultations and priority setting, a portfolio organized by aggregated innovations, or clusters of activities, articulated flagship projects, incentive funding, a dynamic interactive communication ability, and programmatic embedding of strategic and integrated gender research. RTB’s design, governance, and management innovations added value to the combined achievements of the participating centers in science and research for development outcomes, described in the following chapters.