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Elsevier, Bioorganic and Medicinal Chemistry Letters, 13(19), p. 3386-3388

DOI: 10.1016/j.bmcl.2009.05.042

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Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH

Journal article published in 2009 by Geetha Velmourougane, Ravinder Raju, Gabriel Bricard, Jin S. Im, Gurdyal S. Besra ORCID, Steven A. Porcelli, Amy R. Howell ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

An alpha-galactosyl ceramide (alpha-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKT-cell proliferation and elicit T-helper cytokines, IL-4 and IFNgamma. Compound 2 combines the acyl chain of the potent, Th2 biasing alpha-GalCer 1 with a sphingoid base of the same length as that found in OCH, which also exhibits Th2 skewing, Such complementation may enhance cytokine bias, which is thought to be important for therapeutic applications of iNKT cell stimulation. Two related alpha-GalCers, 3 and 4, with saturated acyl chains were prepared for comparison.