Both smartphone addiction and phubbing are emerging behavioral problems. The present study investigates potential risk and protective factors of smartphone addiction and phubbing behavior, including demographic factors, personal factors, and interpersonal factors among Chinese college students. A total of 866 college students (M_age = 21.01, SD = 1.60) completed self-reported questionnaires in classroom settings. Collected data were analyzed by using Pearson’s correlation and hierarchical linear regression analyses. The risk factors for smartphone addiction were phubbing behavior, depression, and social anxiety, while the protective factors were self-control and sense of security. In addition, the risk factors for phubbing behavior included female sex and smartphone addiction, while the protective factors included sense of security and interpersonal adaptability. Our findings help to enhance understanding of the general and specific risks and protective factors for smartphone addiction and phubbing behavior, which can benefit intervention development for related behavior prevention and reduction.