Abstract We present a spatially resolved H ii region study of the gas-phase metallicity, ionization parameter, and interstellar medium (ISM) pressure maps of six local star-forming and face-on spiral galaxies from the TYPHOON program. Self-consistent metallicity, ionization parameter, and pressure maps are calculated simultaneously through an iterative process to provide useful measures of the local chemical abundance and its relation to localized ISM properties. We constrain the presence of azimuthal variations in metallicity by measuring the residual metallicity offset Δ(O/H) after subtracting the linear fits to the radial metallicity profiles. We, however, find weak evidence of azimuthal variations in most of the galaxies, with small (mean 0.03 dex) scatter. The galaxies instead reveal that H ii regions with enhanced and reduced abundances are found distributed throughout the disk. While the spiral pattern plays a role in organizing the ISM, it alone does not establish the relatively uniform azimuthal variations we observe. Differences in the metal abundances are more likely driven by the strong correlations with the local physical conditions. We find a strong and positive correlation between the ionization parameter and the local abundances as measured by the relative metallicity offset Δ(O/H), indicating a tight relationship between local physical conditions and their localized enrichment of the ISM. Additionally, we demonstrate the impact of unresolved observations on the measured ISM properties by rebinning the data cubes to simulate low-resolution (1 kpc) observations, typical of large IFU surveys. We find that the ionization parameter and ISM pressure diagnostics are impacted by the loss of resolution such that their measured values are larger relative to the measured values on sub-H ii region scales.