Repetitive loads acting on the hip joint fluctuate according to the type of activities produced by the human body. Repetitive loading is one of the factors that leads to fatigue failure of the implanted stems. The objective of this study is to develop lightweight femoral stems with cubic porous structures that will survive under fatigue loading. Cubic porous structures with different volumetric porosities were designed and subjected to compressive loading using finite element analysis (FEA) to measure the elastic moduli, yield strength, and ultimate tensile strength. These porous structures were employed to design femoral stems containing mechanical properties under compressive loading close to the intact bone. Several arrangements of radial geometrical porous functionally graded (FG) and homogenous Ti-6Al-4V porous femoral stems were designed and grouped under three average porosities of 30%, 50%, and 70% respectively. The designed stems were simulated inside the femoral bone with physiological loads demonstrating three walking speeds of 1, 3, and 5 km/h using ABAQUS. Stresses at the layers of the functionally graded stem were measured and compared with the yield strength of the relevant porous structure to check the possibility of yielding under the subjected load. The Soderberg approach is employed to compute the safety factor (Nf > 1.0) for each design under each loading condition. Several designs were shortlisted as potential candidates for orthopedic implants.