Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune Evasion
Journal article published in 2022 by
Stephan Brouwer 
,
Magnus G. Jespersen,
Cheryl-Lynn Y. Ong ,
David M. P. De Oliveira ,
Bernhard Keller,
Amanda J. Cork,
Karrera Y. Djoko ,
Mark R. Davies ,
Mark J. Walker
,
Magnus G. Jespersen,
Cheryl-Lynn Y. Ong ,
David M. P. De Oliveira ,
Bernhard Keller,
Amanda J. Cork,
Karrera Y. Djoko ,
Mark R. Davies ,
Mark J. Walker
This paper is made freely available by the publisher.
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Abstract
During infection, microbes must escape host immune responses and survive exposure to reactive oxygen species produced by immune cells. Here, we identify the ABC transporter substrate binding protein GshT as a key component of the glutathione salvage pathway in glutathione-auxotrophic GAS.