The entrainment rate (λ) is difficult to estimate, and its uncertainties cause a significant error in convection parameterization and precipitation simulation, especially over the Tibetan Plateau, where observations are scarce. The λ over the Tibetan Plateau, and its adjacent regions, is estimated for the first time using five-year satellite data and a reanalysis dataset. The λ and cloud base environmental relative humidity (RH) decrease with an increase in terrain height. Quantitatively, the correlation between λ and RH changes from positive at low terrain heights to negative at high terrain heights, and the underlying mechanisms are here interpreted. When the terrain height is below 1 km, large RH decreases the difference in moist static energy (MSE) between the clouds and the environment and increases λ. When the terrain height is above 1 km, the correlation between λ and RH is related to the difference between MSE turning point and cloud base, because of decreases in specific humidity near the surface with increasing terrain height. These results enhance the theoretical understanding of the factors affecting λ and pave the way for improving the parameterization of λ.