In today state of interaction, biological strategies endow us with a green tool for the design of nonmaterials. It is vital to espouse safer substitute strategies to integrate miscellaneous nanoassemblies. Nanomedicine and nano delivery systems are a moderately new but hurriedly mounting science where materials in the nano scale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a proscribed manner. The exploration of nanostructured drug delivery systems allows the encroachment of novel stages for the efficient transport and controlled release of drug molecules in the unsympathetic microenvironment of diseased tissues of living systems. The chapter deals with a brief account of delivery devices produced from green methods and describes site-specific drug delivery systems (including their pros and cons) and their relevance in the field of green nanomedicine.