Self-control has predominantly been characterized as a domain-general individual difference, assuming that highly self-controlled individuals are generally, that is, irrespective of domain, better at resisting their desires. However, qualitative differences in the domains in which these desires emerge and how individuals interact with these domains have rarely been examined. We re-analyzed three experience sampling datasets ( N _participants = 431, N _observations = 15,962) and found that person × domain interactions predicted significant additional variance in momentary self-control above and beyond person differences, ranging from additional 6.2% of variance in desire strength to 17.0% of variance in conflict strength. Moreover, person × domain interactions in resistance strength predicted significantly more variance in resistance success than person or domain differences. Nevertheless, the number of individual resistance profiles was too diverse to be meaningfully reduced to a core set of latent resistance profiles. Thus, our results demonstrate the importance of considering person × domain interactions in future investigations of self-control and show that there is great diversity in how and how successfully different people interact with their self-control conflicts in different domains.