Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci
Journal article published in 2022 by
Katie Saund 
,
Ali Pirani ,
D. Borden Lacy ,
Philip C. Hanna,
Evan Snitkin
,
Ali Pirani ,
D. Borden Lacy ,
Philip C. Hanna,
Evan Snitkin
This paper is made freely available by the publisher.
Full text: Download
Data provided by 
Abstract
Clostridioides difficile has two major disease-mediating toxins, A and B, encoded within the pathogenicity locus (PaLoc). In this study, we demonstrate via multiple approaches that genomic variants outside the PaLoc are associated with changes in cytotoxicity.