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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(66), 2022

DOI: 10.1128/aac.00252-22

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The NaHCO <sub>3</sub> -Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus (MRSA) Is Influenced by mecA Genotype

Journal article published in 2022 by Selvi C. Ersoy ORCID, Adhar C. Manna ORCID, Richard A. Proctor, Henry F. Chambers, Ewan M. Harrison, Arnold S. Bayer, Ambrose Cheung
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) strains are a leading cause of many invasive clinical syndromes, and pose treatment difficulties due to their in vitro resistance to most β-lactams on standard laboratory testing. A novel phenotype frequently identified in MRSA strains, termed ‘NaHCO 3 -responsiveness’, is a property whereby strains are susceptible in vitro to many β-lactams in the presence of NaHCO 3 .