AbstractProvision of safe drinking water (DW) is one of the major requisites for human health, related to four Sustainable Development Goals (SDGs) of the United Nation 2030 Agenda: SDGs 3 (Good health), 6 (Clean water and sanitation), 11 (Sustainable cities) and 12 (Responsible production and consumption). However, this is hindered by the presence, especially in highly-anthropized contexts, of contaminants of emerging concern (CECs) in DW, that may pose a risk for human health. The present study aims at developing a holistic framework to support both (i) decision-makers for CECs prioritization in DW regulation and (ii) water utilities for the selection of appropriate monitoring and treatment interventions for the optimization of DW supply system. In detail, a quantitative chemical risk assessment (QCRA), including uncertainties related to both exposure and hazard assessments, was developed. Then, it was combined with testing and modeling of CECs fate in treatment processes and in distribution network, obtaining a robust tool to achieve the above-mentioned SDGs. Graphical Abstract