PARIS and SPARTA: Finding the Achilles’ Heel of SARS-CoV-2

Simon, Viviana; Kota, Vamsi; Bloomquist, Ryan F.; Hanley, Hannah B.; Forgacs, David; Pahwa, Savita; Pallikkuth, Suresh; Miller, Loren G.; Klebert, M. K.; Turner Wooseob, J. S.; Schaenman, Joanna; Kalaidina, K. E.; Presti, R. M.; O'Halloran, J. A.; Yeaman, Michael R.; Haile, A.; Goss, C. W.; Rauseo, A. M.; Schmitz, A.; Manthei, David; Lei, T.; Williams, E.; Hoffer, M.; Wolf, Joshua; Alshammary, H.; Amoako, A. A.; Andre, D.; Gaur, Aditya H.; Awawda, M. H.; Beach, K.; Bermúdez-González, C.; Bielak, D.; Estepp, Jeremie H.; Cai, G. Y.; Ceglia, I.; Cognigni, C.; Srivastava, Komal; Gleason, C.; Kawabata, H.; Kleiner, G.; Carreño, Juan Manuel; Lyttle, N.; Mendez, W.; Mulder, L. C. F.; Oostenink, A.; Cuevas, Frans; Polanco, J.; Raskin, A.; Rooker, A.; Ellebedy, Ali H.; Salimbangon, A.; Saksena, M.; Singh, G.; Gordon, Aubree; Sominsky, L.; Tcheou, J.; Kowalski-Dobson, T.; Valdez, Riccardo; Gherasim, C.; Stoneman, E.; Kawaoka, Y.; Halfman, P.; Cobey, Sarah; Bakker, K.; Blanc,; Sneeringer, S.; Reed, Elaine F.; Paulauskis, J.; Bird, J.; Warsinske, L.; Kolhe, Ravindra; Chowdhury, M.; Davis, D.; Meyers, A.; Lindsey, K.; Thomas, Paul G.; Tutino, R.; Baker, B.; Bolle, C.; Schultz-Cherry, Stacey; Bratt, D.; Briggs, C.; Buescher, L.; Ross, Ted M.; Burris, J.; Byrne, J.; Carlock, M.; Fagan, P.; Krammer, Florian; Gattiker, J.; Gokanapudi, N.; Hamwy, O.; Hill, T.; Howland, L.; Ji, H.; Mailloux, K.; Phillips, B.; Schmitz, K.; Shi, H.; Smith, C.; Waits, T.; Whitesell, E.; Allen, E. K.; Allison, K.; Hakim, H.; Hayden, R. T.; Hijano, D. R.; Hoffman, J.; McGargill,; Mori, T.; Tang, L.; Tuomanen, E.; Webby, R.; Bajracharya, R.; Cherry, S.; Clark, B. L.; Dallas, R. H.; Fabrizio, T.; Hodges, J.; Gowen, A.; Lin, C.-Y.; Russell-Bell, J.; Sparks, J.; Wittman, D. E.; Van de Velde, L.-A.; Wilson, T. L.; Roubidoux, E. K.; Cortez,; Freiden, P.; Wohlgemuth, N.; Whitt, K.; Farmaha, J.; James, J. N.; Carlock, C. M.; Fransoso, D.; Mondal, A.; Sahajpal, N.; Churchwell, L.; Jones, K.; Ananth, S.; Williams, C.; Patel, R.; Ray, P.; Danielle, B.; Moore, J.; Flores, E.; Kupferwasser, D.; Merino, P.; Tran, D. P.; Jenkins, M. M.; Bi, Q.

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American Society for Microbiology, mSphere, 3(7), 2022

DOI: 10.1128/msphere.00179-22

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PARIS and SPARTA: Finding the Achilles’ Heel of SARS-CoV-2

Journal article published in 2022 by Viviana Simon, Vamsi Kota, Ryan F. Bloomquist, Hannah B. Hanley, David Forgacs, Savita Pahwa, Suresh Pallikkuth, Loren G. Miller, M. K. Klebert, J. S. Turner Wooseob, Joanna Schaenman, K. E. Kalaidina, R. M. Presti, J. A. O'Halloran, Michael R. Yeaman and other authors.

This paper is made freely available by the publisher.

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Abstract

Determining reinfection rates and correlates of protection against SARS-CoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.

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PARIS and SPARTA: Finding the Achilles’ Heel of SARS-CoV-2

Abstract