Abstract We examine and quantify how hybrid (e.g., UV+IR) star formation rate (SFR) estimators and the A _FUV–β relation depend on inclination for disk-dominated galaxies using spectral energy distribution modeling that utilizes the inclination-dependent attenuation curves described in Doore et al. We perform this analysis on a sample of 133 disk-dominated galaxies from the CANDELS fields and 18 disk galaxies from the Spitzer Infrared Nearby Galaxies Survey and Key Insights on Nearby Galaxies: A Far-Infrared Survey with Herschel samples. We find that both the hybrid SFR estimators and the A _FUV–β relation present clear dependencies on inclination. To quantify this dependence in the hybrid SFR estimators, we derive an inclination and a far-UV–near-IR color-dependent parametric relation for converting observed UV and IR luminosities into SFRs. For the A _FUV–β relation, we introduce an inclination-dependent component that accounts for the majority of the inclination dependence with the scatter of the relation increasing with inclination. We then compare both of these inclination-dependent relations to similar inclination-independent relations found in the literature. From this comparison, we find that the UV+IR correction factor and A _FUV for our hybrid and A _FUV–β relations, respectively, result in a reduction in the residual scatter of our sample by approximately a factor of 2. Therefore, we demonstrate that inclination must be considered in hybrid SFR estimators and the A _FUV–β relation to produce more accurate SFR estimates in disk-dominated galaxies.