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Public Library of Science, PLoS ONE, 7(9), p. e100921, 2014

DOI: 10.1371/journal.pone.0100921

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Magnetic resonance colonography for fibrosis assessment in rats with chronic colitis.

Journal article published in 2014 by Chloé Melchior, Emilien Loeuillard, Rachel Marion-Letellier, Lionel Nicol, Paul Mulder ORCID, Charlène Guerin, Christine Bôle-Feysot, Moutaz Aziz, Pierre Déchelotte, Pierre Vera, Guillaume Savoye, Céline Savoye-Collet
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Magnetic resonance colonography (MRC) has been developed to assess inflammatory bowel diseases. We aimed to assess the feasibility of MRC in rats with TNBS-induced chronic colitis and to confront imaging results with fibrosis and stenosing features of the model. Chronic colitis was induced in 12 rats by weekly intra-rectal injection of increasing doses of TNBS for 6 weeks, while 8 control rats received the vehicle. At week 7, MRC was performed. Fibrosis scores were assessed and fibrosis mediators measured. Chronic colitis was associated with significant body weight loss (p